Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the International Atomic Energy Agency
Identifieur interne : 000013 ( Maroc/Analysis ); précédent : 000012; suivant : 000014Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the International Atomic Energy Agency
Auteurs : Eduardo Rosenblatt [Autriche] ; May Abdel-Wahab [Autriche, États-Unis] ; Mahmoud El-Gantiry [Égypte] ; Inas Elattar [Égypte] ; Jean Marc Bourque [Autriche, Canada] ; M Amed Afiane [Algérie] ; Nouredine Benjaafar [Maroc] ; Shahid Abubaker [Pakistan] ; Yaowalak Chansilpa [Thaïlande] ; Bhadrasain Vikram [États-Unis] ; Peter Levendag [Pays-Bas]Source :
- Radiation Oncology (London, England) [ 1748-717X ] ; 2014.
Abstract
The purpose was to determine whether a brachytherapy boost improves outcomes in patients with advanced nasopharyngeal carcinoma treated with standard chemo-radiotherapy.
Patients with nasopharyngeal carcinoma WHO grades I-III and TNM stages III or non-metastatic stage IV were eligible for this phase III study. Patients were randomized to either arm (A) induction chemotherapy, followed by external beam radiotherapy (EBRT) with concomitant cisplatin (n = 139) or arm (B), the same schedule plus a brachytherapy boost to the nasopharynx (n = 135). The EBRT doses given were 70 Gy to the primary tumour and positive lymph nodes and 46 Gy to the negative neck. The additional brachytherapy boost in arm (B) was given by either low dose-rate (LDR – 11 Gy) or high dose-rate (HDR – 3 fractions of 3.0 Gy) brachytherapy. The primary endpoint was 3-year overall survival (OS) and secondary endpoints were: local control, regional control, distant metastasis and grade 3–4 adverse events.
274 patients were randomized between September 2004 and December 2008. The two arms were comparable with regard to age, gender, stage and grade. 273 patients completed treatment. Median follow-up was 29 months (0.2-67 months). The effect of treatment arm, country, age, gender, WHO pathology, stage (T3-4, N2-3 versus other) and chemotherapy on overall survival (OS), disease-free survival (DFS) and local recurrence-free survival (LRFS) was studied. Stage significantly affected OS (p = 0.024) and DFS (p = 0.018) while age significantly affected OS (p = 0.014). None of the other factors studied were significant. The 3-year LRFS was 60.5% and 54.4% in arms A and B respectively (p = 0.647). The 3-year regional control rate in the neck was 59.7% and 54.3% respectively (p = 0.7). Distant metastasis developed in 59.7% of patients in arm A and 55.4% in arm B (p = 0.377). Patients with T1/T2 N + had a 3 year LRFS of 51.8% in Arm A (62 patients) versus 57.9% in Arm B (67 patients) (p = 0.343). The grade 3–4 toxicity rate was 21.6% (30/139) and 24.4% (33/135) respectively (p = 0.687).
The addition of a brachytherapy boost to external beam radiotherapy and chemotherapy did not improve outcome in loco-regionally advanced nasopharyngeal carcinoma.
Url:
DOI: 10.1186/1748-717X-9-67
PubMed: 24581393
PubMed Central: 4018980
Affiliations:
- Algérie, Autriche, Canada, Maroc, Pakistan, Pays-Bas, Thaïlande, Égypte, États-Unis
- Angleterre, Grand Londres, Hollande-Méridionale, Rabat-Salé-Kénitra, Vienne (Autriche), Wilaya d'Alger
- Alger, Londres, Rabat, Rotterdam, Vienne (Autriche)
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000298
- to stream Pmc, to step Curation: 000297
- to stream Pmc, to step Checkpoint: 000155
- to stream Ncbi, to step Merge: 000299
- to stream Ncbi, to step Curation: 000299
- to stream Ncbi, to step Checkpoint: 000299
- to stream Main, to step Merge: 000167
- to stream Main, to step Curation: 000167
- to stream Main, to step Exploration: 000167
- to stream Maroc, to step Extraction: 000013
Links to Exploration step
PMC:4018980Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the International Atomic Energy Agency</title><author><name sortKey="Rosenblatt, Eduardo" sort="Rosenblatt, Eduardo" uniqKey="Rosenblatt E" first="Eduardo" last="Rosenblatt">Eduardo Rosenblatt</name><affiliation wicri:level="3"><nlm:aff id="I1">International Atomic Energy Agency, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>International Atomic Energy Agency, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Abdel Wahab, May" sort="Abdel Wahab, May" uniqKey="Abdel Wahab M" first="May" last="Abdel-Wahab">May Abdel-Wahab</name><affiliation wicri:level="3"><nlm:aff id="I1">International Atomic Energy Agency, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>International Atomic Energy Agency, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Taussig Comprehensive Cancer Center, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taussig Comprehensive Cancer Center, Cleveland Clinic, Cleveland, OH</wicri:regionArea><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="El Gantiry, Mahmoud" sort="El Gantiry, Mahmoud" uniqKey="El Gantiry M" first="Mahmoud" last="El-Gantiry">Mahmoud El-Gantiry</name><affiliation wicri:level="1"><nlm:aff id="I3">National Cancer Institute, University of Cairo, Cairo, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>National Cancer Institute, University of Cairo, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Elattar, Inas" sort="Elattar, Inas" uniqKey="Elattar I" first="Inas" last="Elattar">Inas Elattar</name><affiliation wicri:level="1"><nlm:aff id="I3">National Cancer Institute, University of Cairo, Cairo, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>National Cancer Institute, University of Cairo, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Bourque, Jean Marc" sort="Bourque, Jean Marc" uniqKey="Bourque J" first="Jean Marc" last="Bourque">Jean Marc Bourque</name><affiliation wicri:level="3"><nlm:aff id="I1">International Atomic Energy Agency, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>International Atomic Energy Agency, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I10">London Regional Cancer Program, University of Western Ontario, London, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>London Regional Cancer Program, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Afiane, M Amed" sort="Afiane, M Amed" uniqKey="Afiane M" first="M Amed" last="Afiane">M Amed Afiane</name><affiliation wicri:level="3"><nlm:aff id="I4">Départment de Radiothérapie, Centre Pierre et Marie Curie, Centre Hospitalier Universitaire Mustafa (CHU), Alger, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Départment de Radiothérapie, Centre Pierre et Marie Curie, Centre Hospitalier Universitaire Mustafa (CHU), Alger</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Benjaafar, Nouredine" sort="Benjaafar, Nouredine" uniqKey="Benjaafar N" first="Nouredine" last="Benjaafar">Nouredine Benjaafar</name><affiliation wicri:level="3"><nlm:aff id="I5">Institut National d'Oncologie, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Institut National d'Oncologie, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Abubaker, Shahid" sort="Abubaker, Shahid" uniqKey="Abubaker S" first="Shahid" last="Abubaker">Shahid Abubaker</name><affiliation wicri:level="1"><nlm:aff id="I6">Institute of Nuclear Medicine and Oncology, Pakistan Atomic Energy Commission (PAEC), Lahore, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Institute of Nuclear Medicine and Oncology, Pakistan Atomic Energy Commission (PAEC), Lahore</wicri:regionArea><wicri:noRegion>Lahore</wicri:noRegion></affiliation></author><author><name sortKey="Chansilpa, Yaowalak" sort="Chansilpa, Yaowalak" uniqKey="Chansilpa Y" first="Yaowalak" last="Chansilpa">Yaowalak Chansilpa</name><affiliation wicri:level="1"><nlm:aff id="I7">Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Vikram, Bhadrasain" sort="Vikram, Bhadrasain" uniqKey="Vikram B" first="Bhadrasain" last="Vikram">Bhadrasain Vikram</name><affiliation wicri:level="1"><nlm:aff id="I8">National Cancer Institute, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Institute, Bethesda, MD</wicri:regionArea><wicri:noRegion>MD</wicri:noRegion></affiliation></author><author><name sortKey="Levendag, Peter" sort="Levendag, Peter" uniqKey="Levendag P" first="Peter" last="Levendag">Peter Levendag</name><affiliation wicri:level="3"><nlm:aff id="I9">Erasmus University, Rotterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus University, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24581393</idno><idno type="pmc">4018980</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018980</idno><idno type="RBID">PMC:4018980</idno><idno type="doi">10.1186/1748-717X-9-67</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000298</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000298</idno><idno type="wicri:Area/Pmc/Curation">000297</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000297</idno><idno type="wicri:Area/Pmc/Checkpoint">000155</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000155</idno><idno type="wicri:Area/Ncbi/Merge">000299</idno><idno type="wicri:Area/Ncbi/Curation">000299</idno><idno type="wicri:Area/Ncbi/Checkpoint">000299</idno><idno type="wicri:Area/Main/Merge">000167</idno><idno type="wicri:Area/Main/Curation">000167</idno><idno type="wicri:Area/Main/Exploration">000167</idno><idno type="wicri:Area/Maroc/Extraction">000013</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the International Atomic Energy Agency</title><author><name sortKey="Rosenblatt, Eduardo" sort="Rosenblatt, Eduardo" uniqKey="Rosenblatt E" first="Eduardo" last="Rosenblatt">Eduardo Rosenblatt</name><affiliation wicri:level="3"><nlm:aff id="I1">International Atomic Energy Agency, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>International Atomic Energy Agency, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Abdel Wahab, May" sort="Abdel Wahab, May" uniqKey="Abdel Wahab M" first="May" last="Abdel-Wahab">May Abdel-Wahab</name><affiliation wicri:level="3"><nlm:aff id="I1">International Atomic Energy Agency, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>International Atomic Energy Agency, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Taussig Comprehensive Cancer Center, Cleveland Clinic, Cleveland, OH, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taussig Comprehensive Cancer Center, Cleveland Clinic, Cleveland, OH</wicri:regionArea><wicri:noRegion>OH</wicri:noRegion></affiliation></author><author><name sortKey="El Gantiry, Mahmoud" sort="El Gantiry, Mahmoud" uniqKey="El Gantiry M" first="Mahmoud" last="El-Gantiry">Mahmoud El-Gantiry</name><affiliation wicri:level="1"><nlm:aff id="I3">National Cancer Institute, University of Cairo, Cairo, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>National Cancer Institute, University of Cairo, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Elattar, Inas" sort="Elattar, Inas" uniqKey="Elattar I" first="Inas" last="Elattar">Inas Elattar</name><affiliation wicri:level="1"><nlm:aff id="I3">National Cancer Institute, University of Cairo, Cairo, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>National Cancer Institute, University of Cairo, Cairo</wicri:regionArea><wicri:noRegion>Cairo</wicri:noRegion></affiliation></author><author><name sortKey="Bourque, Jean Marc" sort="Bourque, Jean Marc" uniqKey="Bourque J" first="Jean Marc" last="Bourque">Jean Marc Bourque</name><affiliation wicri:level="3"><nlm:aff id="I1">International Atomic Energy Agency, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>International Atomic Energy Agency, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I10">London Regional Cancer Program, University of Western Ontario, London, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>London Regional Cancer Program, University of Western Ontario, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Afiane, M Amed" sort="Afiane, M Amed" uniqKey="Afiane M" first="M Amed" last="Afiane">M Amed Afiane</name><affiliation wicri:level="3"><nlm:aff id="I4">Départment de Radiothérapie, Centre Pierre et Marie Curie, Centre Hospitalier Universitaire Mustafa (CHU), Alger, Algeria</nlm:aff><country xml:lang="fr">Algérie</country><wicri:regionArea>Départment de Radiothérapie, Centre Pierre et Marie Curie, Centre Hospitalier Universitaire Mustafa (CHU), Alger</wicri:regionArea><placeName><settlement type="city">Alger</settlement><region nuts="2">Wilaya d'Alger</region></placeName></affiliation></author><author><name sortKey="Benjaafar, Nouredine" sort="Benjaafar, Nouredine" uniqKey="Benjaafar N" first="Nouredine" last="Benjaafar">Nouredine Benjaafar</name><affiliation wicri:level="3"><nlm:aff id="I5">Institut National d'Oncologie, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Institut National d'Oncologie, Rabat</wicri:regionArea><placeName><settlement type="city">Rabat</settlement><region nuts="2">Rabat-Salé-Kénitra</region></placeName></affiliation></author><author><name sortKey="Abubaker, Shahid" sort="Abubaker, Shahid" uniqKey="Abubaker S" first="Shahid" last="Abubaker">Shahid Abubaker</name><affiliation wicri:level="1"><nlm:aff id="I6">Institute of Nuclear Medicine and Oncology, Pakistan Atomic Energy Commission (PAEC), Lahore, Pakistan</nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea>Institute of Nuclear Medicine and Oncology, Pakistan Atomic Energy Commission (PAEC), Lahore</wicri:regionArea><wicri:noRegion>Lahore</wicri:noRegion></affiliation></author><author><name sortKey="Chansilpa, Yaowalak" sort="Chansilpa, Yaowalak" uniqKey="Chansilpa Y" first="Yaowalak" last="Chansilpa">Yaowalak Chansilpa</name><affiliation wicri:level="1"><nlm:aff id="I7">Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand</nlm:aff><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Vikram, Bhadrasain" sort="Vikram, Bhadrasain" uniqKey="Vikram B" first="Bhadrasain" last="Vikram">Bhadrasain Vikram</name><affiliation wicri:level="1"><nlm:aff id="I8">National Cancer Institute, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Institute, Bethesda, MD</wicri:regionArea><wicri:noRegion>MD</wicri:noRegion></affiliation></author><author><name sortKey="Levendag, Peter" sort="Levendag, Peter" uniqKey="Levendag P" first="Peter" last="Levendag">Peter Levendag</name><affiliation wicri:level="3"><nlm:aff id="I9">Erasmus University, Rotterdam, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus University, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Radiation Oncology (London, England)</title><idno type="eISSN">1748-717X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Abstact</title><sec><title>Background</title><p>The purpose was to determine whether a brachytherapy boost improves outcomes in patients with advanced nasopharyngeal carcinoma treated with standard chemo-radiotherapy.</p></sec><sec><title>Methods</title><p>Patients with nasopharyngeal carcinoma WHO grades I-III and TNM stages III or non-metastatic stage IV were eligible for this phase III study. Patients were randomized to either arm (A) induction chemotherapy, followed by external beam radiotherapy (EBRT) with concomitant cisplatin (n = 139) or arm (B), the same schedule plus a brachytherapy boost to the nasopharynx (n = 135). The EBRT doses given were 70 Gy to the primary tumour and positive lymph nodes and 46 Gy to the negative neck. The additional brachytherapy boost in arm (B) was given by either low dose-rate (LDR – 11 Gy) or high dose-rate (HDR – 3 fractions of 3.0 Gy) brachytherapy. The primary endpoint was 3-year overall survival (OS) and secondary endpoints were: local control, regional control, distant metastasis and grade 3–4 adverse events.</p></sec><sec><title>Results</title><p>274 patients were randomized between September 2004 and December 2008. The two arms were comparable with regard to age, gender, stage and grade. 273 patients completed treatment. Median follow-up was 29 months (0.2-67 months). The effect of treatment arm, country, age, gender, WHO pathology, stage (T3-4, N2-3 versus other) and chemotherapy on overall survival (OS), disease-free survival (DFS) and local recurrence-free survival (LRFS) was studied. Stage significantly affected OS (p = 0.024) and DFS (p = 0.018) while age significantly affected OS (p = 0.014). None of the other factors studied were significant. The 3-year LRFS was 60.5% and 54.4% in arms A and B respectively (p = 0.647). The 3-year regional control rate in the neck was 59.7% and 54.3% respectively (p = 0.7). Distant metastasis developed in 59.7% of patients in arm A and 55.4% in arm B (p = 0.377). Patients with T1/T2 N + had a 3 year LRFS of 51.8% in Arm A (62 patients) versus 57.9% in Arm B (67 patients) (p = 0.343). The grade 3–4 toxicity rate was 21.6% (30/139) and 24.4% (33/135) respectively (p = 0.687).</p></sec><sec><title>Conclusions</title><p>The addition of a brachytherapy boost to external beam radiotherapy and chemotherapy did not improve outcome in loco-regionally advanced nasopharyngeal carcinoma.</p></sec></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lee, Aw" uniqKey="Lee A">AW Lee</name></author><author><name sortKey="Poon, Yf" uniqKey="Poon Y">YF Poon</name></author><author><name sortKey="Foo, W" uniqKey="Foo W">W Foo</name></author><author><name sortKey="Law, Sc" uniqKey="Law S">SC Law</name></author><author><name sortKey="Chueng, Fk" uniqKey="Chueng F">FK Chueng</name></author><author><name sortKey="Chan, Dk" uniqKey="Chan D">DK Chan</name></author><author><name sortKey="Tung, Sy" uniqKey="Tung S">SY Tung</name></author><author><name sortKey="Thaw, M" uniqKey="Thaw M">M Thaw</name></author><author><name sortKey="Ho, Jh" uniqKey="Ho J">JH Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwong, Dl" uniqKey="Kwong D">DL Kwong</name></author><author><name sortKey="Sham, Js" uniqKey="Sham J">JS Sham</name></author><author><name sortKey="Choy, D" uniqKey="Choy D">D Choy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Awm" uniqKey="Lee A">AWM Lee</name></author><author><name sortKey="Chan, Dkk" uniqKey="Chan D">DKK Chan</name></author><author><name sortKey="Fowler, Jf" uniqKey="Fowler J">JF Fowler</name></author><author><name sortKey="Poon, Yf" uniqKey="Poon Y">YF Poon</name></author><author><name sortKey="Foo, W" uniqKey="Foo W">W Foo</name></author><author><name sortKey="O, Sk" uniqKey="O S">SK O</name></author><author><name sortKey="Law, Sck" uniqKey="Law S">SCK Law</name></author><author><name sortKey="Tung, Sy" uniqKey="Tung S">SY Tung</name></author><author><name sortKey="Chappell, R" uniqKey="Chappell R">R Chappell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez, Ca" uniqKey="Perez C">CA Perez</name></author><author><name sortKey="Devineni, Vr" uniqKey="Devineni V">VR Devineni</name></author><author><name sortKey="Marcial Vega, V" uniqKey="Marcial Vega V">V Marcial-Vega</name></author><author><name sortKey="Marks, Je" uniqKey="Marks J">JE Marks</name></author><author><name sortKey="Simpson, Jr" uniqKey="Simpson J">JR Simpson</name></author><author><name sortKey="Kucik, N" uniqKey="Kucik N">N Kucik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Sarraf, M" uniqKey="Al Sarraf M">M Al-Sarraf</name></author><author><name sortKey="Leblanc, M" uniqKey="Leblanc M">M LeBlanc</name></author><author><name sortKey="Giri, Pg" uniqKey="Giri P">PG Giri</name></author><author><name sortKey="Fu, Kk" uniqKey="Fu K">KK Fu</name></author><author><name sortKey="Cooper, J" uniqKey="Cooper J">J Cooper</name></author><author><name sortKey="Vuong, T" uniqKey="Vuong T">T Vuong</name></author><author><name sortKey="Forastiere, Aa" uniqKey="Forastiere A">AA Forastiere</name></author><author><name sortKey="Adams, G" uniqKey="Adams G">G Adams</name></author><author><name sortKey="Sakr, Wa" uniqKey="Sakr W">WA Sakr</name></author><author><name sortKey="Schuller, De" uniqKey="Schuller D">DE Schuller</name></author><author><name sortKey="Ensley, Jf" uniqKey="Ensley J">JF Ensley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levendag, Pc" uniqKey="Levendag P">PC Levendag</name></author><author><name sortKey="Peters, R" uniqKey="Peters R">R Peters</name></author><author><name sortKey="Meeuwis, Ca" uniqKey="Meeuwis C">CA Meeuwis</name></author><author><name sortKey="Visch, Ll" uniqKey="Visch L">LL Visch</name></author><author><name sortKey="Sipkema, D" uniqKey="Sipkema D">D Sipkema</name></author><author><name sortKey="De Pan, C" uniqKey="De Pan C">C de Pan</name></author><author><name sortKey="Schmitz, Pim" uniqKey="Schmitz P">PIM Schmitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tate, Dj" uniqKey="Tate D">DJ Tate</name></author><author><name sortKey="Adler, Jr" uniqKey="Adler J">JR Adler</name></author><author><name sortKey="Chang, Sd" uniqKey="Chang S">SD Chang</name></author><author><name sortKey="Marquez, S" uniqKey="Marquez S">S Marquez</name></author><author><name sortKey="Eulau, Sm" uniqKey="Eulau S">SM Eulau</name></author><author><name sortKey="Fee, We" uniqKey="Fee W">WE Fee</name></author><author><name sortKey="Pinto, H" uniqKey="Pinto H">H Pinto</name></author><author><name sortKey="Goffinet, Dr" uniqKey="Goffinet D">DR Goffinet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Xia, P" uniqKey="Xia P">P Xia</name></author><author><name sortKey="Quivey, Jm" uniqKey="Quivey J">JM Quivey</name></author><author><name sortKey="Sultanem, K" uniqKey="Sultanem K">K Sultanem</name></author><author><name sortKey="Poon, I" uniqKey="Poon I">I Poon</name></author><author><name sortKey="Akazawa, C" uniqKey="Akazawa C">C Akazawa</name></author><author><name sortKey="Akazawa, P" uniqKey="Akazawa P">P Akazawa</name></author><author><name sortKey="Weinberg, V" uniqKey="Weinberg V">V Weinberg</name></author><author><name sortKey="Fu, Kk" uniqKey="Fu K">KK Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chua, Dtt" uniqKey="Chua D">DTT Chua</name></author><author><name sortKey="Sham, Jst" uniqKey="Sham J">JST Sham</name></author><author><name sortKey="Kwong, Pwk" uniqKey="Kwong P">PWK Kwong</name></author><author><name sortKey="Hung, K N" uniqKey="Hung K">K-N Hung</name></author><author><name sortKey="Leung, Lht" uniqKey="Leung L">LHT Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kam, Mkm" uniqKey="Kam M">MKM Kam</name></author><author><name sortKey="Teo, Pml" uniqKey="Teo P">PML Teo</name></author><author><name sortKey="Chau, Rmc" uniqKey="Chau R">RMC Chau</name></author><author><name sortKey="Cheung, Ky" uniqKey="Cheung K">KY Cheung</name></author><author><name sortKey="Choi, Phk" uniqKey="Choi P">PHK Choi</name></author><author><name sortKey="Kwan, Wh" uniqKey="Kwan W">WH Kwan</name></author><author><name sortKey="Leung, Sf" uniqKey="Leung S">SF Leung</name></author><author><name sortKey="Zee, B" uniqKey="Zee B">B Zee</name></author><author><name sortKey="Chan, Atc" uniqKey="Chan A">ATC Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Awm" uniqKey="Lee A">AWM Lee</name></author><author><name sortKey="Sze, Wm" uniqKey="Sze W">WM Sze</name></author><author><name sortKey="Au, Jsk" uniqKey="Au J">JSK Au</name></author><author><name sortKey="Leung, Sf" uniqKey="Leung S">SF Leung</name></author><author><name sortKey="Leung, Tw" uniqKey="Leung T">TW Leung</name></author><author><name sortKey="Chua, Dtt" uniqKey="Chua D">DTT Chua</name></author><author><name sortKey="Zee, Bcy" uniqKey="Zee B">BCY Zee</name></author><author><name sortKey="Law, Sck" uniqKey="Law S">SCK Law</name></author><author><name sortKey="Teo, Pml" uniqKey="Teo P">PML Teo</name></author><author><name sortKey="Tung, Sy" uniqKey="Tung S">SY Tung</name></author><author><name sortKey="Kwong, Dlw" uniqKey="Kwong D">DLW Kwong</name></author><author><name sortKey="Lau, Wh" uniqKey="Lau W">WH Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Syed, Amn" uniqKey="Syed A">AMN Syed</name></author><author><name sortKey="Puthawala, Aa" uniqKey="Puthawala A">AA Puthawala</name></author><author><name sortKey="Damore, Sj" uniqKey="Damore S">SJ Damore</name></author><author><name sortKey="Cherlow, Jm" uniqKey="Cherlow J">JM Cherlow</name></author><author><name sortKey="Austin, Pa" uniqKey="Austin P">PA Austin</name></author><author><name sortKey="Sposto, R" uniqKey="Sposto R">R Sposto</name></author><author><name sortKey="Ramsinghani, Ns" uniqKey="Ramsinghani N">NS Ramsinghani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levendag, Pc" uniqKey="Levendag P">PC Levendag</name></author><author><name sortKey="Schmitz, Pi" uniqKey="Schmitz P">PI Schmitz</name></author><author><name sortKey="Jansen, Pp" uniqKey="Jansen P">PP Jansen</name></author><author><name sortKey="Eijkenboom, Wm" uniqKey="Eijkenboom W">WM Eijkenboom</name></author><author><name sortKey="Visser, Ag" uniqKey="Visser A">AG Visser</name></author><author><name sortKey="Kolkman Deurloo, I Kk" uniqKey="Kolkman Deurloo I">I-KK Kolkman-Deurloo</name></author><author><name sortKey="Sipkema, D" uniqKey="Sipkema D">D Sipkema</name></author><author><name sortKey="Visch, Ll" uniqKey="Visch L">LL Visch</name></author><author><name sortKey="Senan, S" uniqKey="Senan S">S Senan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Jt" uniqKey="Chang J">JT Chang</name></author><author><name sortKey="See, Lc" uniqKey="See L">LC See</name></author><author><name sortKey="Tang, Sg" uniqKey="Tang S">SG Tang</name></author><author><name sortKey="Lee, Sp" uniqKey="Lee S">SP Lee</name></author><author><name sortKey="Wang, Cc" uniqKey="Wang C">CC Wang</name></author><author><name sortKey="Hong, Jh" uniqKey="Hong J">JH Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levendag, Pc" uniqKey="Levendag P">PC Levendag</name></author><author><name sortKey="Lagerwaard, Fj" uniqKey="Lagerwaard F">FJ Lagerwaard</name></author><author><name sortKey="Noever, I" uniqKey="Noever I">I Noever</name></author><author><name sortKey="De Pan, C" uniqKey="De Pan C">C de Pan</name></author><author><name sortKey="Van Nimwegen, A" uniqKey="Van Nimwegen A">A van Nimwegen</name></author><author><name sortKey="Wijers, O" uniqKey="Wijers O">O Wijers</name></author><author><name sortKey="Schmitz, P" uniqKey="Schmitz P">P Schmitz</name></author><author><name sortKey="Van Dieren, E" uniqKey="Van Dieren E">E van Dieren</name></author><author><name sortKey="Nowak, Pj" uniqKey="Nowak P">PJ Nowak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teo, Pm" uniqKey="Teo P">PM Teo</name></author><author><name sortKey="Leung, Sf" uniqKey="Leung S">SF Leung</name></author><author><name sortKey="Lee, Wy" uniqKey="Lee W">WY Lee</name></author><author><name sortKey="Zee, B" uniqKey="Zee B">B Zee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozyar, E" uniqKey="Ozyar E">E Ozyar</name></author><author><name sortKey="Yildz, F" uniqKey="Yildz F">F Yildz</name></author><author><name sortKey="Akyol, Fh" uniqKey="Akyol F">FH Akyol</name></author><author><name sortKey="Atahan, Il" uniqKey="Atahan I">IL Atahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Tw" uniqKey="Leung T">TW Leung</name></author><author><name sortKey="Wong, Vy" uniqKey="Wong V">VY Wong</name></author><author><name sortKey="Sze, Wk" uniqKey="Sze W">WK Sze</name></author><author><name sortKey="Lui, Cm" uniqKey="Lui C">CM Lui</name></author><author><name sortKey="Tung, Sy" uniqKey="Tung S">SY Tung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, C" uniqKey="Chang C">C Chang</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Chang, Y" uniqKey="Chang Y">Y Chang</name></author><author><name sortKey="Cao, S" uniqKey="Cao S">S Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sham, Js" uniqKey="Sham J">JS Sham</name></author><author><name sortKey="Choy, D" uniqKey="Choy D">D Choy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baujat, B" uniqKey="Baujat B">B Baujat</name></author><author><name sortKey="Audry, H" uniqKey="Audry H">H Audry</name></author><author><name sortKey="Bourhis, J" uniqKey="Bourhis J">J Bourhis</name></author><author><name sortKey="Chan, Atc" uniqKey="Chan A">ATC Chan</name></author><author><name sortKey="Onat, H" uniqKey="Onat H">H Onat</name></author><author><name sortKey="Chua, Dtt" uniqKey="Chua D">DTT Chua</name></author><author><name sortKey="Kwong, Dlw" uniqKey="Kwong D">DLW Kwong</name></author><author><name sortKey="Al Sarraf, M" uniqKey="Al Sarraf M">M Al-Sarraf</name></author><author><name sortKey="Chi, K H" uniqKey="Chi K">K-H Chi</name></author><author><name sortKey="Hareyama, M" uniqKey="Hareyama M">M Hareyama</name></author><author><name sortKey="Leung, Sf" uniqKey="Leung S">SF Leung</name></author><author><name sortKey="Thephamongkhol, K" uniqKey="Thephamongkhol K">K Thephamongkhol</name></author><author><name sortKey="Pignon, J P" uniqKey="Pignon J">J-P Pignon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dimery, Iw" uniqKey="Dimery I">IW Dimery</name></author><author><name sortKey="Peters, Lj" uniqKey="Peters L">LJ Peters</name></author><author><name sortKey="Goepfert, H" uniqKey="Goepfert H">H Goepfert</name></author><author><name sortKey="Morrison, Wh" uniqKey="Morrison W">WH Morrison</name></author><author><name sortKey="Byers, Rm" uniqKey="Byers R">RM Byers</name></author><author><name sortKey="Guillory, C" uniqKey="Guillory C">C Guillory</name></author><author><name sortKey="Mccarthy, K" uniqKey="Mccarthy K">K McCarthy</name></author><author><name sortKey="Weber, Rs" uniqKey="Weber R">RS Weber</name></author><author><name sortKey="Hong, Wk" uniqKey="Hong W">WK Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Ep" uniqKey="Hui E">EP Hui</name></author><author><name sortKey="Ma, Bb" uniqKey="Ma B">BB Ma</name></author><author><name sortKey="Leung, Sf" uniqKey="Leung S">SF Leung</name></author><author><name sortKey="King, Ad" uniqKey="King A">AD King</name></author><author><name sortKey="Mo, F" uniqKey="Mo F">F Mo</name></author><author><name sortKey="Kam, Mk" uniqKey="Kam M">MK Kam</name></author><author><name sortKey="Yu, Bk" uniqKey="Yu B">BK Yu</name></author><author><name sortKey="Chiu, Sk" uniqKey="Chiu S">SK Chiu</name></author><author><name sortKey="Kwan, Wh" uniqKey="Kwan W">WH Kwan</name></author><author><name sortKey="Ho, R" uniqKey="Ho R">R Ho</name></author><author><name sortKey="Chan, I" uniqKey="Chan I">I Chan</name></author><author><name sortKey="Ahuja, At" uniqKey="Ahuja A">AT Ahuja</name></author><author><name sortKey="Zee, Bc" uniqKey="Zee B">BC Zee</name></author><author><name sortKey="Chan, At" uniqKey="Chan A">AT Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chua, Dt" uniqKey="Chua D">DT Chua</name></author><author><name sortKey="Sham, Js" uniqKey="Sham J">JS Sham</name></author><author><name sortKey="Choy, D" uniqKey="Choy D">D Choy</name></author><author><name sortKey="Lorvidhaya, V" uniqKey="Lorvidhaya V">V Lorvidhaya</name></author><author><name sortKey="Sumitsawan, Y" uniqKey="Sumitsawan Y">Y Sumitsawan</name></author><author><name sortKey="Thongprasert, S" uniqKey="Thongprasert S">S Thongprasert</name></author><author><name sortKey="Vootiprux, V" uniqKey="Vootiprux V">V Vootiprux</name></author><author><name sortKey="Cheirsilpa, A" uniqKey="Cheirsilpa A">A Cheirsilpa</name></author><author><name sortKey="Azhar, T" uniqKey="Azhar T">T Azhar</name></author><author><name sortKey="Reksodiputro, Ah" uniqKey="Reksodiputro A">AH Reksodiputro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Mai, H Q" uniqKey="Mai H">H-Q Mai</name></author><author><name sortKey="Hong, M H" uniqKey="Hong M">M-H Hong</name></author><author><name sortKey="Min, H Q" uniqKey="Min H">H-Q Min</name></author><author><name sortKey="Mao, Z D" uniqKey="Mao Z">Z-D Mao</name></author><author><name sortKey="Cui, N J" uniqKey="Cui N">N-J Cui</name></author><author><name sortKey="Lu, T X" uniqKey="Lu T">T-X Lu</name></author><author><name sortKey="Mo, H Y" uniqKey="Mo H">H-Y Mo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levendag, Pc" uniqKey="Levendag P">PC Levendag</name></author><author><name sortKey="Keskin Cambay, F" uniqKey="Keskin Cambay F">F Keskin-Cambay</name></author><author><name sortKey="Teguh, Dn" uniqKey="Teguh D">DN Teguh</name></author><author><name sortKey="El Gantiry, M" uniqKey="El Gantiry M">M El-Gantiry</name></author><author><name sortKey="Wildeman, Ma" uniqKey="Wildeman M">MA Wildeman</name></author><author><name sortKey="De Pan, C" uniqKey="De Pan C">C de Pan</name></author><author><name sortKey="Vikram, B" uniqKey="Vikram B">B Vikram</name></author><author><name sortKey="Abdel Wahab, M" uniqKey="Abdel Wahab M">M Abdel-Wahab</name></author><author><name sortKey="Rosenblatt, E" uniqKey="Rosenblatt E">E Rosenblatt</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Algérie</li><li>Autriche</li><li>Canada</li><li>Maroc</li><li>Pakistan</li><li>Pays-Bas</li><li>Thaïlande</li><li>Égypte</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Rabat-Salé-Kénitra</li><li>Vienne (Autriche)</li><li>Wilaya d'Alger</li></region><settlement><li>Alger</li><li>Londres</li><li>Rabat</li><li>Rotterdam</li><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Rosenblatt, Eduardo" sort="Rosenblatt, Eduardo" uniqKey="Rosenblatt E" first="Eduardo" last="Rosenblatt">Eduardo Rosenblatt</name></region><name sortKey="Abdel Wahab, May" sort="Abdel Wahab, May" uniqKey="Abdel Wahab M" first="May" last="Abdel-Wahab">May Abdel-Wahab</name><name sortKey="Bourque, Jean Marc" sort="Bourque, Jean Marc" uniqKey="Bourque J" first="Jean Marc" last="Bourque">Jean Marc Bourque</name></country><country name="États-Unis"><noRegion><name sortKey="Abdel Wahab, May" sort="Abdel Wahab, May" uniqKey="Abdel Wahab M" first="May" last="Abdel-Wahab">May Abdel-Wahab</name></noRegion><name sortKey="Vikram, Bhadrasain" sort="Vikram, Bhadrasain" uniqKey="Vikram B" first="Bhadrasain" last="Vikram">Bhadrasain Vikram</name></country><country name="Égypte"><noRegion><name sortKey="El Gantiry, Mahmoud" sort="El Gantiry, Mahmoud" uniqKey="El Gantiry M" first="Mahmoud" last="El-Gantiry">Mahmoud El-Gantiry</name></noRegion><name sortKey="Elattar, Inas" sort="Elattar, Inas" uniqKey="Elattar I" first="Inas" last="Elattar">Inas Elattar</name></country><country name="Canada"><region name="Angleterre"><name sortKey="Bourque, Jean Marc" sort="Bourque, Jean Marc" uniqKey="Bourque J" first="Jean Marc" last="Bourque">Jean Marc Bourque</name></region></country><country name="Algérie"><region name="Wilaya d'Alger"><name sortKey="Afiane, M Amed" sort="Afiane, M Amed" uniqKey="Afiane M" first="M Amed" last="Afiane">M Amed Afiane</name></region></country><country name="Maroc"><region name="Rabat-Salé-Kénitra"><name sortKey="Benjaafar, Nouredine" sort="Benjaafar, Nouredine" uniqKey="Benjaafar N" first="Nouredine" last="Benjaafar">Nouredine Benjaafar</name></region></country><country name="Pakistan"><noRegion><name sortKey="Abubaker, Shahid" sort="Abubaker, Shahid" uniqKey="Abubaker S" first="Shahid" last="Abubaker">Shahid Abubaker</name></noRegion></country><country name="Thaïlande"><noRegion><name sortKey="Chansilpa, Yaowalak" sort="Chansilpa, Yaowalak" uniqKey="Chansilpa Y" first="Yaowalak" last="Chansilpa">Yaowalak Chansilpa</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Levendag, Peter" sort="Levendag, Peter" uniqKey="Levendag P" first="Peter" last="Levendag">Peter Levendag</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Maroc/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000013 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Maroc/Analysis/biblio.hfd -nk 000013 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= CobaltMaghrebV1
|flux= Maroc
|étape= Analysis
|type= RBID
|clé= PMC:4018980
|texte= Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the International Atomic Energy Agency
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Maroc/Analysis/RBID.i -Sk "pubmed:24581393" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Maroc/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a CobaltMaghrebV1
| This area was generated with Dilib version V0.6.32. |  |